Aleksandra Gasecka

Aleksandra Gąsecka

My name is Aleksandra Gasecka and I am a cardiologist in training and a post-doc at the 1st Chair and Department of Cardiology of the Medical University of Warsaw, Poland, working in collaboration with the Laboratory of Experimental Clinical Chemistry in the Academic Medical Center of the University of Amsterdam, The Netherlands. I am interested in extracellular vesicles as biomarkers for cardiovascular disease. This website contains information related to my research interests and other activities. Below, you can find an overview of my publications.

News

Nov 24th, 2020  Our manuscript showing that endovascular repair of thoraco-abdominal aortic aneurysm induces a transient deterioration of diastolic function in patients with high cardiovascular risk is accepted for publication in Journal of Cardiothoracic and Vascular Anesthesia.
Nov 22th, 2020  Our manuscript demonstrating that D-dimer levels predict COVID-19 severity and mortality is accepted for publication in Polish Heart Journal.
Nov 18th, 2020  Our manuscript about predictors and biomarkers of subclinical leaflet thrombosis after transcatheter aortic valve implantation is accepted for publication in Journal of Clinical Medicine.
Nov 19th, 2020  I received a scientific award from the Polish Ministry of Health for the research work on antiplatelet therapy, including the project entitled: "Platelet extracellular vesicles and the use of P2Y12 receptor antagonists in acute myocardial infarction".
Oct 15th, 2020  Our manuscript "Antiplatelet effects of prostacyclin analogues – which one to choose in case of thrombosis or bleeding?" is accepted for publication in Cardiology Journal.
Sep 16th, 2020  I received two grants from the Polish Cardiac Society: a Young Researcher's Grant for the project: "Platelet extracellular vesicles to predict subclinical leaflet thrombosis after transcatheter aortic valve implantation" (50,000 PLN) and a Specialized Research Fellowship Grant for the project "Platelet extracellular vesicles as biomarkers of developing coronary thrombosis" (10,000 €). The grants were awarded at the Inaugural Session of the XXIV International Congress of the Polish Cardiac Society.
Sep 15th, 2020  Our manuscript about thrombotic complications in patients with COVID-19, written together with the members of Young Thrombosis Researchers Group, Working Group on Thrombosis, European Society of Cardiology is accepted for publication in Cardiovascular Drugs and Therapy .
Aug 28th, 2020  Our editorial "Impaired microcirculation function in COVID-19 and implications for potential therapies" is accepted for publication in Cardiology Journal.
Aug 27th, 2020  Our article about early biomarkers of neurodegenerative and neurovascular disorders in diabetes is accepted for publication in Journal of Clinical Medicine.
Aug 25th, 2020  Our article "Circulating microRNA in heart failure - practical guidebook to clinical application" is accepted for publication in Cardiology in Review.
Aug 23th, 2020  Our review regarding the role of P2Y receptors in platelet extracellular vesicles release is accepted for publication in International Journal of Molecular Sciences.
July 22nd, 2020  I gave two presentations at ISEV2020 Virtual Annual Meeting : "Prostanoids impair platelet reactivity, thrombus formation and platelet extracellular vesicle release in patients with pulmonary arterial hypertension" and "Release of extracellular vesicles from platelets requires platelet-platelet interaction".
June 4th, 2020  Our case report about persistent myocardial ischaemia due to anaemia in patient with coeliac disease is accepted for publication in Heart International.
June 3rd, 2020  I gave a presentation about calibrated flow cytometry to measure the concentration of extracellular vesicles in patients with myocardial infarction during the online EV Flow Cytometry Seminar Series. The presentation is available on YouTube.
May 21st, 2020  I obtained a PhD title cum laude for the dissertation "Platelets extracellular vesicles and treatment with P2Y12 antagonists in acute myocardial infarction" at the Medical University of Warsaw.
April 24th, 2020  Our manuscript showing that inflammatory state does not affect the antiplatelet efficacy of potent P2Y12 inhibitors in ACS is accepted for publication in Platelets.
Jan 19th, 2020  Our case report about a rare presentation of MSSA cardiac device related infected endocarditis is accepted for publication in Clinical Microbiology and Infection.
December 5th, 2019 I received a scholarship from the Foundation for the Development of the Medical University of Warsaw for an internship in National Institutes of Health , Washington, DC.
November 27th, 2019 Our manuscript about ticagrelor which attenuates the increase of extracellular vesicles concentrations in plasma after acute myocardial infarction compared to clopidogrel, is accepted for publication in Journal of Thrombosis and Haemostasis.
September 18th, 2019  I gave a presentation about bottlenecks in isolation and characterisation of extracellular vesicles (EVs), and procoagulant tissue factor on EVs at DGTI 2019 in Mannheim, Germany.
Aug 31st, 2019  I gave a presentation about antiplatelet therapy effect on extracellular vesicles in acute myocardial infarction at ESC 2019 in Paris, France.
Aug 23th, 2019  Our manuscript about a uremic toxin trimethylamine-N-oxide (TMA), which is involved in cardiovascular pathology, is accepted for publication in Toxins.
May 17th, 2019  I received PRELUDIUM Grant from the National Science Centre, Poland (210,000 PLN) for the study Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 receptor antagonists.
April 27th, 2019  I gave a presentation about platelet extracellular vesicles as first liquid biopsy biomarkers to diagnose acute ischaemic stroke at ISEV 2019 in Kyoto, Japan.
April 25th, 2019  I gave a presentation about identification of extracellular vesicles as biomarkers for myocardial infraction by flow cytometry and automated data processing at ISEV 2019 in Kyoto, Japan.
March 28th, 2019  Our book chapter about platelet-derived extracellular vesicles is published in the 4th edition of Platelets.
February 7th, 2019  I gave a presentation about ticagrelor effect on extracellular vesicles in acute myocardial infarction at Astra Zeneca Cardiovascular, Renal and Metabolism Research Summit in Madrid, Spain.
January 12th, 2019  Our manuscript about switching between P2Y12 antagonists is accepted for publication in Vascular Pharmacology.
November 12th, 2018  Our randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles in acute myocardial infarction is accepted for publication in Platelets.
November 7th, 2018  I gave a presentation about changes in extracellular vesicles concentrations after acute myocardial infarction at NLSEV 2018 in Amsterdam, The Netherlands.
August 28th, 2018 I received Young Researcher’s Grant of the Medical University of Warsaw (50,000 PLN) for the study Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction (AFFECT EV).
May 25th, 2018 Our manuscript about hollow organosilica beads as reference particles for optical detection of extracellular vesicles, is accepted for publication in Journal of Thrombosis and Haemostasis.
April 22nd, 2018 I gave a presentation about technical issues in extracellular vesicle research in cardiovascular system at Frontiers in CardioVascular Biology 2018 in Vienna, Austria.
April 6th, 2018 Our manuscript about P2Y12 antagonist ticagrelor, which inhibits the release of procoagulant extracellular vesicles from activated platelets, is accepted for publication in Cardiology Journal.
February 15th, 2018 Our manuscript about dysregulations of microRNAs and galectin-3 in patients with systolic heart failure is accepted for publication in Polish Heart Journal.
January 17th, 2018 Our manuscript about the pleiotropic effects of ticagrelor is accepted for publication in Therapeutics and Clinical Risk Management.
September 6th, 2017 Our manuscript about extracellular vesicles in post-infarct ventricular remodelling is accepted for publication in Polish Heart Journal.
September 1st, 2017 I started a 12-month research internship at the Laboratory of Experimental Clinical Chemistry in the Academic Medical Center under the supervision of Dr. Rienk Nieuwland.
August 12th, 2017  Our manuscript about prasugrel which decreases the extent of periprocedural myocardial injury during elective percutaneous coronary intervention is accepted for publication in Polish Archives of Internal Medicine.
July 9th, 2017  I presented a poster about the P2Y1 and P2Y12 antagonists which mediate the release and composition of platelet extracellular vesicles at ISTH 2017 in Berlin, Germany .
May 12th, 2017  Our methodological guidelines to study extracellular vesicles are accepted for publication in Circulation Research.
December 22nd, 2016  I received Externally Sponsored Scientific Research Grant from AstraZeneca and MedImmune for the study Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction (AFFECT EV).
October 19th, 2016  Our manuscript about platelet extracellular vesicles as biomarkers for arterial thrombosis is accepted for publication in Platelets.
October 4th, 2016  Our manuscript about cell-derived microvesicles in cardiovascular diseases and antiplatelet therapy monitoring is accepted for publication in International Journal of Cardiology.
August 22nd, 2016  I presented a poster about the role of P2Y1 and P2Y12 receptors in release of platelet-derived extracellular vesicles at Gordon Research Conference 2016 in Sunday River, Maine, US .